Assoc Prof Daniel Mucida

Assoc Prof Daniel Mucida

The Rockefeller University, New York, NY, USA pic-mucida

Visit co-ordinated by Fernando Souza-Fonseca-Guimaraes guimaraes.f@wehi.edu.au

Itinerary/seminars

10 March Seminar and meetings at the University of New South Wales, Sydney (host: Mate Biro)

13-14 March Seminar and meetings at the Malaghan Institute, Wellington, NZ (host: Kara Filbey)

16-17 March Seminar and meetings at the WEHI and University of Melbourne, Melbourne (hosts: Daniel Mucida and Laura Mackay)

Biography

Daniel Mucida received his B.S. in Biology, with emphasis in Biochemistry and Immunology, from the Federal University of Minas Gerais (Brazil) in 2000. He received his Ph.D. (Immunology) in 2005 from the University of São Paulo and New York University. After completing his postdoctoral research at La Jolla Institute for Allergy and Immunology, he joined Rockefeller’s faculty in 2010. One of the goals of his laboratory is to characterize the cellular and molecular mechanisms that lead to the development of pro-inflammatory and regulatory cells at the mucosal surfaces, both from the innate and the adaptive immune system. Dr. Mucida has shown that the intestine is able to efficiently induce regulatory lymphocytes that can prevent allergy and other inflammatory processes using metabolites derived from diet. He has found that a vitamin A metabolite, retinoic acid, produced by intestinal dendritic cells, is able to modulate the development of inflammatory and regulatory cells.  A second interest of Dr. Mucida’s lab is to understand how exposure to different classes of commensal bacteria affects the development and differentiation of immune cells and susceptibility to inflammatory processes. The crucial role of the microbiota for the development and maturation of the immune system is demonstrated by studies on germ-free animals, which bear an immature immune system. Although CD4 helper T cells are crucial for the generation of efficient immune responses, uncontrolled CD4 helper T cells can pose a threat to an organism, particularly in chronically stimulated sites such as the mucosal surfaces.