Prof. Ralph Tripp

Ralph Tripp

Prof. Ralph Tripp

Professor and Georgia Research Alliance Chair of Vaccine & Therapeutic Studies

University of Georgia, Athens, GA, USA

Prof. Ralph Tripp will attend the ASI conference in Canberra and will visit several branches.

Details of the visit to be announced

Hosted by Reena Ghildyal, University of Canberra, ACT

 

My overall research interest is to develop translational disease intervention strategies for important human pathogens and emerging infectious diseases of zoonotic origin. My labs investigate the mechanisms of immunity, the virus-host interface and disease pathogenesis to influenza virus to understand the dynamics of host response to infection and to provide new strategies for resolving disease. I trained in the field of viral immunity studying immune evasion of adenoviruses with Dr. Linda Gooding at Emory University, and then T cell immunology and viral immunology with Laureate Professor Peter C. Doherty at St. Jude Children’s Research. Subsequently, I led a research team in vaccine studies for human viral diseases in the Respiratory and Enteric Viruses Branch at the CDC, and now at the Animal Health Research Center (AHRC) at the Univ Georgia which is BSL2/BSL3+ biocontainment facility.

 

Selected publications in the last 3 years

Powell JD, Dlugolenski D, Nagy T, Gabbard J, Lee C, Tompkins SM, Tripp RA. Polymerase Discordance in Novel Swine Influenza H3N2v Constellations Is Tolerated in Swine but Not Human Respiratory Epithelial Cells. PLoS One. 2014 Oct 16;9(10):e110264.

Tripp RA, Mark Tompkins S. Antiviral effects of inhibiting host gene expression. Curr Top Microbiol Immunol. 2015;386:459-77.

Perwitasari O, Johnson S, Yan X, Howerth E, Shacham S, Landesman Y, Baloglu E, McCauley D, Tamir S, Tompkins SM, Tripp RA. Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo. J Virol. 2014 Sep 1;88(17):10228-43.

Fox JM, Sage LK, Poore S, Johnson S, Tompkins SM, Tripp RA. Drug analog inhibition of indoleamine 2,3-dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection. J Leukoc Biol. 2014 Sep;96(3):447-52.

Phan SI, Chen Z, Xu P, Li Z, Gao X, Foster SL, Teng MN, Tripp RA, Sakamoto K, He B. A respiratory syncytial virus (RSV) vaccine based on parainfluenza virus 5 (PIV5). Vaccine. 2014 May 23;32(25):3050-7.

Sage LK, Fox JM, Mellor AL, Tompkins SM, Tripp RA. Indoleamine 2,3-dioxygenase (IDO) activity during the primary immune response to influenza infection modifies the memory T cell response to influenza challenge. Viral Immunol. 2014 Apr;27(3):112-23.

Jorquera PA, Choi Y, Oakley KE, Powell TJ, Boyd JG, Palath N, Haynes LM, Anderson LJ, Tripp RA. Nanoparticle Vaccines Encompassing the Respiratory Syncytial Virus (RSV) G Protein CX3C Chemokine Motif Induce Robust Immunity Protecting from Challenge and Disease. PLoS One. 2013 PMID: 24040360

Fouchier RA, Kawaoka Y, Cardona C, Compans RW, García-Sastre A, Govorkova EA, Guan Y, Herfst S, Orenstein WA, Peiris JS, Perez DR, Richt JA, Russell C, Schultz-Cherry SL, Smith DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG.  Gain-of-Function Experiments on H7N9. Science. 2013 PMID: 23926190

Fouchier RA, Kawaoka Y, Cardona C, Compans RW, García-Sastre A, Govorkova EA, Guan Y, Herfst S, Orenstein WA, Peiris JS, Perez DR, Richt JA, Russell C, Schultz-Cherry SL, Smith DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG.Gain-of-Function Experiments on H7N9. Science. 2013 PMID: 23926190

Fouchier RA, Kawaoka Y, Cardona C, Compans RW, Fouchier RA, García-Sastre A, Govorkova EA, Guan Y, Herfst S, Kawaoka Y, Orenstein WA, Peiris JS, Perez DR, Richt JA, Russell C, Schultz-Cherry SL, Smith DJ, Steel J, Tompkins SM, Topham DJ, Treanor JJ, Tripp RA, Webby RJ, Webster RG. Avian flu: Gain-of-function experiments on H7N9. Nature. 2013 PMID: 23925229

Turner TM, Jones LP, Tompkins SM, Tripp RA.  A Novel Influenza Virus Hemagglutinin-Respiratory Syncytial Virus (RSV) Fusion Protein Subunit Vaccine against Influenza and RSV.J Virol. 2013 PMID: 23903841

Sage LK, Fox JM, Tompkins SM, Tripp RA. Subsisting H1N1 Influenza Memory Responses are Insufficient to Protect from Pandemic H1N1 Influenza Challenge in C57BL/6 Mice. J Gen Virol. 2013 PMID: 23580424

Fouchier RA, García-Sastre A, Kawaoka Y, Barclay WS, Bouvier NM, Brown IH, Capua I, Chen H, Compans RW, Couch RB, Cox NJ, Doherty PC, Donis RO, Feldmann H, Guan Y, Katz JM, Kiselev OI, Klenk HD, Kobinger G, Liu J, Liu X, Lowen A, Mettenleiter TC, Osterhaus AD, Palese P, Peiris JS, Perez DR, Richt JA, Schultz-Cherry S, Steel J, Subbarao K, Swayne DE, Takimoto T, Tashiro M, Taubenberger JK, Thomas PG, Tripp RA, Tumpey TM, Webby RJ, Webster RG.  Transmission studies resume for avian flu. Science. 2013 Feb 1;339(6119):520-1. PMID: 23345603

Bakre A, Mitchell P, Coleman JK, Jones LP, Saavedra G, Teng M, Tompkins SM, Tripp RA. Respiratory syncytial virus modifies microRNAs regulating host genes that affect virus replication. J Gen Virol. 2012 Nov;93(Pt 11):2346-56. PMID: 22894925

Meliopoulos VA, Andersen LE, Brooks P, Yan X, Bakre A, Coleman JK, Tompkins SM, Tripp RA. MicroRNA regulation of human protease genes essential for influenza virus replication. PLoS One. 2012;7(5) PMID: 22606348

Choi Y, Mason CS, Jones LP, Crabtree J, Jorquera PA, Tripp RA.Antibodies to the central conserved region of respiratory syncytial virus (RSV) G protein block RSV G protein CX3C-CX3CR1 binding and cross-neutralize RSV A and B strains. Viral Immunol. 2012 Jun;25(3):193-203. PMID: 22551066