Professor Daniel Altmann

Altmann photo

 

Imperial College

London, UK

Hosted by Natkunam Ketheesan, James Cook University, Townsville

April/May 2015

Prof. Altman has confirmed he will visit Sydney, Brisbane and Townsville.

 

Professor Daniel Altmann heads the Human Disease Immunogenetics Group at the Hammersmith Campus, Imperial College. Key research interests are the immunology of autoimmune diseases and of bacterial infections. His work is centred on the use of molecular and cellular immunology approaches to investigate interactions between HLA class II molecules, antigenic peptides, CD4 T cells and NK cells in disease.

Multiple sclerosis has been a particular focus of interest within the Altmann lab. Working with the UK MS Tissue Bank they have gained a better understanding of patient T cell responses to myelin epitopes, HLA-C/KIR genotypes and the relationship of these to disease. They have also generated 'humanised,' spontaneous models of MS, which serve better to bridge the translational gap between findings in the EAE model and the clinical disease setting. Their work on MS is support by the Wellcome Trust, BBSRC and MS Society.

A second area of research addresses issues of T cell immune responses to bacterial infection. The group has been a recipient of an NIH-NIAID multi-million dollar research grant to define and characterise immune epitopes from anthrax (Bacillus anthracis) and plague (Yersinia pestis).  The project is part of an international endeavour to define microbial epitopes for the Immune Epitope Database (www.IEDB.org). Through another NIH-NIAID-funded research programme, his group is currently mapping the CD4 and CD8 T cell epitopes of Burkholderia pseudomallei as part of an international consortium. Current research funded by the Medical Research Council (MRC) also focuses on molecular analysis of toxic shock and on regulatory T cell control of acute infection.   

 

Selected Key publications:

Altmann, D.M., Douek, D.C., Frater, A.J., Inoko, H., Hetherington, C.M. and Elliott, J.I., 1995. T cell responses of HLA-DR transgenic mice to human myelin basic protein and other antigens in the presence and absence of a human CD4 transgene. J. Exp. Med. ,181, 867

Elliott, J.I. & Altmann, D.M., 1995. Dual TCRa T cells in autoimmune disease. J. Exp. Med. 182, 953

Birk, O., Douek, D.C., Takacs, K., Dewchand, H., Hetherington, C.M., Elias, D., Walker, M., Cohen, I.R. and Altmann, D.M., 1996. A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model. Proc. Natl. Acad. Sci USA93, 1032

Altmann, D.M. (2006). T cell immunity and prion-protein 129 polymorphism in CJD. Lancet Neurol. 7. 554-555.

Campbell JD, Buckland KF, McMillan SJ, Kearley J, Oldfield WLG, Stern LJ, Gronlund H, van Hage M, Reynolds CJ, Boyton RJ, Cobbold SP, Kay AB, Altmann* DM, Lloyd* CM, Larche* M. Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression_ J Exp Med 206(7):1535-1547. *joint senior authors

Ingram RJ, Metan G, Maillere B, Doganay M, Ozkul Y, Kim LU, Baillie L, Dyson H, Williamson ED, Chu KK, Ascough S, Moore S, Huwar TB, Robinson JH, Sriskandan S, Altmann DM. 2010. Natural exposure to cutaneous anthrax gives long-lasting T cell immunity encompassing infection-specific epitopes._ J Immunol 184(7):3814-3821

Ingram RJ, Chu KK, Metan G, Maillere B, Doganay M, Ozkul Y, Dyson H, Williamson ED, Baillie L, Kim LU, Ascough S, Sriskandan S, Altmann DM. 2010. An epitope of Bacillus anthracis protective antigen that is cryptic in rabbits may be immunodominant in humans. Infect Immun 78(5):2353

Chu KK, Tippayawat P, Walker NJ, Harding SV, Atkins HS, Maillere B, Bancroft GJ, Lertmemongkolchai G, Altmann DM. 2011. CD4+ T-cell immunity to the Burkholderia pseudomallei ABC transporter LolC in melioidosis. Eur J Immunol. 41(1):107-15.

Durrenberger PF, Ettorre A, Kamel F, Webb LV, Sim M, Nicholas RS, Malik O, Reynolds R, Boyton RJ, Altmann DM. 2012. Innate immunity in multiple sclerosis white matter lesions: expression of natural cytotoxicity triggering receptor 1 (NCR1). J  euroinflammation. 2012 Jan 2;9:1.

Ascough S., R.J. Ingram, K.K. Chu, G. Metan, B. Maillere, M. Doganay, Y. Ozkul, L. U. Kim, S. Sriskandan and D. M. Altmann. 2012. Anthrax Vaccine Induced immunodominant Protective Antigen Epitopes Are Also Stimulated By Natural Infection. J. Immunology, 188, 5205

Boyton RJ, Reynolds CJ, Quigley KJ, Altmann DM., 2013. Immune mechanisms and the impact of the disrupted lung microbiome in chronic bacterial lung infection and bronchiectasis. Clin Exp Immunol. 171(2):117-23.

Boyton RJ, Altmann DM. 2012 Immune regulation in idiopathic bronchiectasis. Ann N Y Acad Sci. 2012 Dec;1272:68-72.

Nicholas R, Dahdaleh D, Altmann DM, Malik O. 2013. Tuberculosis in London: not unexpected. Lancet. 381 (9862):201-2

Altmann D, Aseffa A, Bash M, Basta N, Borrow R, Broome C, Caugant D, Clark T, Collard JM, Djingarey M, Goldblatt D, Greenwood B, Griffiths U, Hajjeh R, Hassan-King M, Hugonnet S, Kimball AM, LaForce M, MacLennan C, Maiden MC, Manigart O, Mayer L, Messonnier N, Moisi J, Moore K, Moto DD, Mueller J, Nascimento M, Obaro S, Ouedraogo R, Page AL, Perea W, Pluschke G, Preziosi MP, Sow S, Stephens D, Stuart J, Thomson M, Tiendrebeogo S, Trape JF, Vernet G. 2013. Priorities for research on meningococcal disease and the impact of serogroup A vaccination in the African meningitis belt. Vaccine. 2013 Mar 1;31(11):1453-7.

Lowther DE, Chong DL, Ascough S, Ettorre A, Ingram RJ, Boyton RJ, Altmann DM.2013 Th1 not Th17 cells drive spontaneous MS-like disease despite a functional regulatory T cell response. Acta Neuropathol. 2013 Oct;126(4):501-15.

Ascough S, Ingram RJ, Chu KK, Reynolds CJ, Musson JA, Doganay M, Metan G, Ozkul Y, Baillie L, Sriskandan S, Moore SJ, Gallagher TB, Dyson H, Williamson ED, Robinson JH, Maillere B, Boyton RJ, Altmann DM. 2014. Anthrax lethal factor as an immune target in humans and transgenic mice and the impact of HLA polymorphism on CD4+ T cell immunity. PLoS Pathog. May 1;10(5):e1004085.