|Name:||A/Prof. Scott Mueller|
|Address/affiliation:||Peter Doherty Institute (PDI) and the Department of Microbiology and Immunology at The University of Melbourne|
The IgV is the Victorian and Tasmanian regional branch of the Australasian Society for Immunology (ASI). Committee members are elected from several different biomedical institutes across the region, and oversee activities for local members.
Nicole La Gruta (Monash University) – President The IgV Committee
Sarah Londrigan (Doherty Institute/The University of Melbourne) - Secretary
Dan Andrews (Monash University) – Treasurer
Scott Mueller (Doherty Institute/The University of Melbourne) - ASI State Councillor
Stuart Berzins (Federation University)
Melissa Call (WEHI)
Mark Chong (SVI)
Phil Darcy (Peter MacCallum Cancer Centre)
Daniel Gray (WEHI)
Nick Huntington (WEHI)
Mireille Lahoud (Monash University)
Daniel Layton (CSIRO)
Bruce Lyons (University of Tasmania)
Ashley Mansell (Hudson Institute/Monash University)
Lisa Mielke (Olivia Newton-John Cancer Centre)
Clare Slaney (Peter MacCallum Cancer Centre)
Marios Koutsakos (Doherty Institute/The University of Melbourne)
Rosie Millen (Peter MacCallum Cancer Centre)
Immune Reactivity and Tolerance Symposium
On March 20th, ASI and IgV are holding a FREE symposium at WEHI. It will feature presentations from ASI visiting speaker, Prof Diane Mathis and Prof Christophe Benoist (both from Harvard Medical School, USA) on their latest work in this area. In addition, there will be a range of talks from local PhD students and early career researchers on this important theme in immunology. Morning tea and lunch will be provided, so please register for this free event at Eventbrite.com.au. More information about the event and the program can also be found on the Eventbrite page. We hope to see you there!
When: March 20th, 9:30am - 2:00pm
Where: The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville
Find the Flyer here: Mini-symposium flyer
ASI Visiting speakers
The following ASI visiting speakers will be coming to Victoria/Tasmania in 2018:
Dr Alan Sher
NIH Distinguished Investigator, National Institute of Allergy and Infectious Diseases
Visit co-ordinated by Carl Feng
"Immunometabolic targets for host-directed therapy of tuberculosis"
Tuberculosis is a disease in need of an effective immunologic intervention. Mycobacterium tuberculosis (Mtb) infection still kills over 1.3 million annually, has no reliable vaccine and is treatable only with an extensive 6-9 month course of antibiotics that is frequently associated with non-compliance, relapse and the development of drug resistance. Our lab employs murine infection models to identify potential targets in the host-Mtb-encounter that could lead to a more rapid and efficient elimination of the pathogen. In previously published studies, we demonstrated host arachidonic acid metabolism as one such host target showing that the generation of PGE2 through this pathway is highly protective and described a host-directed therapy that promotes its induction. In our more recent work, we have been able to substantially enhance host control of the pathogen with agents that either prevent the metabolic release of iron (an essential nutrient for MTb) or block iron dependent necrotic cell death (ferroptosis) of infected cells. In the former case, we have been able to combine the repurposed drug employed with conventional antibiotics to achieve both enhanced and accelerated bacterial clearance.
This work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, NIH, USA.
Locations and dates:
1. The University of Tasmania: Thursday March 22nd, 1-2:00 pm
Lecture Theatre 115, Medical Science Precinct, 17 Liverpool Street, Hobart
Videocast to room M209, Launceston
contact: Guna Karupiah
2. Peter Doherty Institute: Friday March 23rd, 1:00-2:00pm, Doherty Auditorium
contact: Scott Mueller or Siddhartha Mahanty
3. Monash University / Hudson Institute: Monday March 26th, 12-1:00pm
contact: Ashley Mansell
Dr. Sher received his Ph.D. in 1972 from the University of California, San Diego, working with Dr. Melvin Cohn at the Salk Institute for Biological Studies. He performed his postdoctoral training in the Division of Parasitology at the National Institute for Medical Research in Mill Hill, London. In 1980, after several years as a research associate and then assistant professor in the Department of Pathology at Harvard Medical School, Sher joined NIAID as a section head in the Laboratory of Parasitic Diseases and from 2002- 2017 served as Chief of that NIH department.
Although initially trained as a basic immunologist, Dr. Sher has devoted most of his career to the study of immunity and immune regulation in parasitic and mycobacterial infections. His group played a pioneering role in defining the effector functions of Th1 and Th2 subsets in the response to parasites later linking them to innate signals triggered by these pathogens in dendritic cells. At the same time Sher and his colleagues helped define the regulatory pathways which prevent immunopathology in polarized anti-parasitic responses and in particular elucidating the role of Interleukin-10 induction in that process. In more recent work, the Sher lab has focused on cytokine and eicosanoid pathways regulating host resistance to Mycobacterium tuberculosis along with other strategies for host directed therapy of this major pathogen and participated in related clinical collaborations in India, Brazil and South Africa.
Dr. Sher is an elected member of the American Academy for the Advancement of Science (AAAS), the American Academy of Microbiology and the Brazilian Academy of Sciences. He is a recipient of the Bonazinga Award (Society for Leukocyte Biology), the Bailey K. Ashford Medal (American Society for Tropical Medicine and Hygiene), the USPHS Superior Service Award and the NIH Director’s Mentoring Award. Sher holds adjunct faculty positions at the Universities of Pennsylvania and Virginia.
Prof Diane Mathis
Visit co-ordinated by Daniel Gray
March 2018: Please see details of the Immune Reactivity and Tolerance symposium, above.
Prof Joel Ernst
Visits co-ordinated by Antje Blumenthal
Prof Uri Hershberg
Visits co-ordinated by Kim Jacobson
Prof Arne Akbar
Visits co-ordinated by Kylie Quinn