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Friday November 11, 2016

CTI Special Feature on Inflammatory Diseases: A Translational Perspective

Special Feature Coordinator: Dr Connie Wong, Centre for Inflammatory Diseases, Department of Medicine, School of Clinical Sciences, Monash Medical Centre, Monash University, Clayton, Victoria 3168, Australia.

Immune homeostasis relies on fine-tuned responses aimed at defending the host, protecting it from infection and promoting repair from injury. However, this process can go amiss, resulting in the development of inflammatory diseases. Despite very different aetiologies and clinical presentations, recent research findings in the physiopathology and treatment of inflammatory diseases prompt us to consider them as a whole. These are chronic, often incapacitating and painful illnesses that may have initiated in an acute localised manner, but progressed into systemic manifestations and destroy organs. In many cases, our understanding of inflammatory disease biology is limited and available therapies vary greatly in their efficacy and safety. In this Special Feature of Clinical & Translational Immunology, leading exponents of inflammatory disease discuss the development of anti-inflammatory treatments in their respective fields and describe the efforts into translating results from promising preclinical animal studies to novel therapeutic strategies for humans.

CTI Special Feature on Inflammatory Diseases: A Translational Perspective

CTI Special Feature on Innate Immune Responses and Vaccine Design

Special Feature Coordinators: Christopher Sundling and Kerrie Sandgren.

The challenge of developing next generation vaccines against some of the most burdensome diseases—both infectious and inflammatory, will require an injection of basic knowledge as well as scientific innovation. As highlighted in this collection of expert reviews, the innate immune response is a critical stepping-stone between vaccination and the development of effective adaptive immunity, triggering and shaping the ensuing cellular and humoral responses that will ultimately control the disease. An enhanced understanding of how innate immunity develops in different disease states will help inform the design and formulation of new vaccine components. Conversely, an increased understanding of the mechanism of action of novel adjuvants will aid in their rational selection for different diseases and delivery platforms. In this Special Feature of Clinical and Translational Immunology, we present a number of papers that jointly highlight the interplay between innate immune responses and the resulting functional vaccine responses.

CTI Special Feature on Innate Immune Responses and Vaccine Design